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Research News

 

Monitoring Post-Mortem Gene Transcription in Mice and Zebrafish

January 26 , 2017

Genes linked to embryonic development, stress, and cancer were among those increasingly transcribed into RNA, researchers at the University of Washington and their colleagues reported. The results suggest that organismal death is an orderly, predictable process, and could help forensic scientists pinpoint time of death, plus help explain why organs from recently deceased donors seem to be more prone to cancer... Read more...


 

 

 

 

 

 

 

 

 

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Short Bowel Syndrome Results in Changes to Gene Expression

January 25 , 2017

Investigators at Children's Hospital Los Angeles have mapped the genetic changes resulting from short bowel syndrome (SBS) using a novel zebrafish model and by performing intensive gene sequencing. This approach to determining which genes are markedly over or under expressed in SBS may assist scientists in developing future therapies for children and adults with this condition... Read more...


Researchers Manipulate Gene Expression Using Light, Create Double-Headed Zebrafish

January 24 , 2017

A Hokkaido University researcher has successfully developed a method to accurately manipulate gene expression by light illumination and demonstrated its usability by creating double-headed zebrafish... Read more...


Zebrafish May Hold the Answer to Why Early Life Stress Can Make You Sick When You’re an Adult

January 23 , 2017

A developing fetus is buffered from a lot of things, but if a pregnant woman is chronically stressed, she is probably releasing a lot of stress hormone cortisol into her bloodstream. The extra cortisol may make the fetus more vulnerable to certain diseases as an adult. Dr. Coffman and his team turned to common aquarium fish for answers – the zebrafish... Read more...


Zebrafish Might Hold the Key to Fighting Leukemia

January 5 , 2017

A new research project is using zebrafish to identify genetic and environmental factors that may lead to childhood leukemia... Read more...


Fishing for Answers: New Insights into Childhood Brain Tumor Treatment

December 13 , 2016

The pressing challenge when treating childhood cancers isn't only to help the patients survive.  It's also essential to protect the child's future quality of life.  Tumors created in zebrafish were similar to human tumors at a genetic level.  Now there is links between certain types of fish tumors and specific types of childhood brain tumors... Read more...


Fixing a Broken Heart: Scientists Try to Regenerate Mammal Heart Using Zebrafish

December 1 , 2016

Scientists are currently in pursuit of treatments that could overcome multiple heart diseases including the broken heart disease.  A team of scientists from the Swanson School of Engineering published a report about the possibility of organ regeneration amongst higher forms of mammals... Read more...


Brain Cancer Breakthrough: Microglia Cells, in Zebrafish, Found to Aid Rather than Fight Against Tumor Growth

December 1 , 2016

Scientists in Edinburgh have discovered that immune cells in the brain encourage tumor cell growth.  They recorded video footage of zebrafish that showed specialized cells, microglia, that interact with cells from glioblastoma.  Gliobastoma is the move common type of brain tumor, which is also the hardest to treat... Read more...


Common Probiotics Can Reduce Stress Levels, Lessen Anxiety

November 21 , 2016

Probiotics have become increasingly popular as a way to improve health and well-being.  Now researchers, using a zebrafish model, have found that common probiotics sold in supplements and yogurt can decrease stress-related behaviors and anxiety... Read more...


G Protein-Coupled Estrogen Receptor Regulates Heart Rate in Zebrafish Embryos

November 21 , 2016

Estrogens act by binding to estrogen receptors that play crucial roles in sex differentiation, tumor growth and cardiovascular physiology.  Estrogen receptor is required to maintain normal heart rate in zebrafish embryos... Read more...


Key Protein for Spinal Cord Repair Identified by Scientist at Due Univertisy

November 6 , 2016

Scientists at Duke University in the US found a particular protein important for the process which could generate new leads into tissue repair in humans... Read more...


Zebrafish Embryo 'Selfie' Takes Top Prize in Microscopic Photo Contest

October 20 , 2016

The tiny face of a four-day old zebrafish embryo, scales of a butterfly's wing and magnified coffee crystals -- just some of the miniature worlds revealed by the 2016 finalists in Nikon's annual microscopic images competition... Read more...


Tweaking Immune Response May Help Fight Neurodegeneration: Study

October 19 , 2016

DRESDEN, Germany, Oct. 19 (UPI) -- Manipulating immune responses may help patients with Alzheimer's disease recover from neurodegenerative damage, researchers in Germany say... Read more...


In Laboratories Across India, Scientists Take Heart From This Little Fish

October 10 , 2016

CCMB is studying the function of Hox genes that help shape the body’s axis while the embryo is formed... Read more...


Gadsden State C.C. Instructor Lauded by International Association

September 14 , 2016

Congratulations to Dr. Hugh Hammer of Gadsden State Community College. Dr Hammer has received the Outstanding Steward Award from the Zebrafish Husbandry Association, an international nonprofit organization devoted to promoting and developing zebrafish husbandry standards through education, collaboration and publication. Hammer received the award during the World Aquaculture Society conference in Las Vegas. Read more...


ACOA to Zebrafish: Dalhousie University Gets Help in Orphan Disease Research

September 13 , 2016

The federal government has invested $3 million in new biotech startups through a Dalhousie University project aimed at battling rare diseases, in part using tiny fish genetically similar to humans but easier to care for than lab rats. Read more...


What Can Modern Fish and Salamander Genes Tell Us About How our Limbs Evolved?

September 11 , 2016

New research from the University of Chicago suggests that an evolutionary link does exist between fish fins and mammalian hands. In the study, researchers eliminated select Hox genes, which give segments in the body identity, from the genomes of zebrafish and mice. They found that the mutations led to a mouse limb with no fingers, and a zebrafish fin with significantly reduced fin bones. Read more...
See video: https://youtu.be/rFjxJELnN4k


See Video: What Can Modern Fish and Salamander Genes Tell Us About How our Limbs Evolved?

September 11 , 2016

In a video for Science Friday, researchers at the University of California-Irvine illustrate how axolotls can even grow extra limbs, like a third arm. When a wound is grafted with skin from another area of the axolotl's arm with a different positional value, the newly neighboring cells of the wound and graft can “fill in” what would normally lie between them, like an arm... Read more...


Zebrafish A New Weapon in War on Superbugs

September 2 , 2016

Using translucent zebrafish infected with glow-in-the-dark bacterial cells, Monash University scientists have been able to watch the war that breaks out in the body during an infection in real time... Read more...


Magneto Manipulates Bbehavior of Freely Moving Mice and Zebrafish

June 23 , 2016

A modified protein allows researchers to use a magnet to switch on neurons anywhere in the brain in freely moving mice and zebrafish. The tool, described in May in Nature Neuroscience, could shed light on neural circuits underlying autism-like behaviors in animal models of the condition... Read more...


Hundreds of Genes Seen Sparking to Life Two Days after Death

June 21 , 2016

Peter Noble and Alex Pozhitkov at the University of Washington, Seattle, and their colleagues investigated the activity of genes in the organs of mice and zebrafish immediately after death. They did this by measuring the amount of messenger RNA present. An increase in this mRNA – which genes use to tell cells to make products such as proteins – indicates that genes are more active... Read more...


Aggressive Cancer Cells Halted

June 10 , 2016

Zebrafish-human communication shows that cancer cells lacking a signaling protein are less able to develop aggressive metastatic properties. This discovery has been made by Claudia Tulotta. PhD defence 14 June... Read more...


A Good Day for Zebrafish

June 9 , 2016

Why zebrafish represent a miracle for the economics of lab-testing — and why rats are overpriced... Read more...


Comparative Epigenomic Profiling of the DNA Methylome in Mouse and Zebrafish Uncovers High Interspecies Divergence

June 9 , 2016

We used comparative methylome analysis of base-resolution DNA methylation profiles from the liver and brain of mouse and zebrafish generated by reduced representation bisulfite sequencing, to identify the conserved and divergent aspects of the methylome in these commonly used vertebrate model organisms... Read more...


Personality Changes Can Affect Body Shape And Movement, Fish Study Reveals

June 5 , 2016

When zebrafish were bred for certain personality traits – such as boldness or shyness – they exhibited changes in “unrelated” traits such as body shape and locomotion. This new research from the North Carolina State University is potentially useful in animal breeding, pest management, as well as studying different human behaviors... Read more...


Zebrafish Lab at St. Michael’s Helps Identify New Genetic Disease and Possible Treatment

May 31 , 2016

The Zebrafish Centre for Advanced Drug Discover at St. Michael's Hospital played a key role in a new study that identified a new genetic disease and helped explain why the brain and the skeleton need a specific sugar to develop properly... Read more...


Fish Courtship Pheromone Uses the Brain's Smell Pathway

May 30 , 2016

Research at the RIKEN Brain Science Institute in Japan has revealed that a molecule involved in fish reproduction activates the brain via the nose. The pheromone is released by female zebrafish and sensed by smell receptors in the noses of the males... Read more...


DNA 'Tape Recorder' to Trace Cell History

May 28 , 2016

Researchers have invented a DNA "tape recorder" that can trace the family history of every cell in an organism... Read more...


List Analysis for Human Diseases Modeled by Zebrafish

May 26 , 2016

List Analysis  for  Human Diseases Modeled by Zebrafish 26 May 2016  (148 DO Terms)... Read more...


Zebrafish Germ Cells Cancer Tumors

May 13 , 2016

Germ cell tumors (GCTs) are malignant cancers that arise from embryonic precursors known as Primordial Germ Cells. GCTs occur in neonates, children, adolescents and young adults and can occur in the testis, the ovary or extragonadal sites... Read more...


Stem Cell Researchers Use Zebrafish to Understand the Role of Cartilage in Bone Repair

May 13 , 2016

In a new study published in  Development , USC Stem Cell researchers Sandeep Paul, Simone Schindler and colleagues use the regeneration of the zebrafish jawbone to show that this is not necessarily true... Read more...


In Vivo Physiological Recording From the Lateral Line of Juvenile Zebrafish

May 13 , 2016

Hair cells are sensory receptors responsible for transducing auditory and vestibular information into electrical signals, which are then transmitted with remarkable precision to afferent neurons. The zebrafish lateral line is emerging as an excellent  in vivo  model... Read more...


Watching Apoptosis in 3D

May 9 , 2016

A promising approach for watching cell signaling processes in their physiological context: Scientists visualize apoptosis in live zebrafish using fluorescence lifetime imaging with optical projection tomography to map FRET biosensor activity in space and time... Read more...


Studying Zebrafish May Provide Insight On Rare Genetic Blood Disorders

May 8 , 2016

Comparing the blood systems of humans to that of the zebrafish, researchers found that the small tropical freshwater fish may provide an effective model of study when learning about rare genetic blood disorders. Dr. Terence Flotte, editor-in-chief of the journal where the study was published... Read more...


How Macrophages Repair Brain Bleeding

May 8 , 2016

New research from Southwest University in China has shown how macrophages help with the repair broken blood vessels. Prior to the study, biologists were unsure about how the brain deals with broken blood vessels and how capable the immune system is with dealing with such incidents. Read more...


Zebrafish Help in the Fight Against Cancer

April 5 , 2016

Scientists at the University of Toledo's college of medicine and life sciences, the former Medical College of Ohio, have begun using a zebrafish model as a new way of screening anti-cancer drugs. Read more...


Microcystin-LR Exposure Induces Developmental Neurotoxicity in Zebrafish Embryo

April 5 , 2016

Read more...


Transgenic Zebrafish Forms Technicolour 'Skinbow'

March 22 , 2016

Researchers have created a transgenic zebrafish with skin that fluoresces in thousands of colours — enabling them to track the behaviour of hundreds of individual cells in real time and to see what happens to skin when it is wounded. Read more...


This Tiny Fish Might Unlock the Brain's Mysteries - and It’s Coming to U of T

March 20 , 2016

Thanks to a successful Canada Foundation for Innovation (CFI) grant, fundamental research into how the zebrafish brain functions will take place at U of T Scarborough. Read more...


Identification of Neuromedin U as a Sleep Regulator

March 7 , 2016

The first large scale screening in zebrafish helped biologists at the California Institute of Technology to identify a gene Neuromedin U (Nmu) which leads to severe insomnia when over activated. Read more...


A Single Cell Shines New Light on How Cancers Develop

March 3 , 2016 , The New York Times

Dr. Leonard Zon of Boston Children’s Hospital, Dr. Charles K. Kaufman, and their colleagues, in a study published Thursday in the journal Science that offers new insight into how cancers may develop. The researchers stumbled on that first cell of a melanoma when they set out to solve a puzzle that has baffled cancer investigator. Read more...


See Video: A Zebrafish Genetic Screen Identifies Nmu as a Sleep Regulator

February 21 , 2016

Chiu et al. perform a genetic screen in zebrafish and identify Nmu as a regulator of sleep/wake behaviors. They show that Nmu overexpression activates brainstem Crh neurons and that Nmu-induced arousal requires Crh signaling, thus identifying a novel vertebrate arousal circuit. Read more...


Zebrafish Embryos Exposed to Atrazine Pass on Health Problems to Their Young

February 19 , 2016

WEST LAFAYETTE, Ind. — Atrazine exposure during embryonic development could cause later reproductive problems for female zebrafish, as well as physical deformations in their offspring, according to new research from Purdue University. Read more...


Research at Bar Harbor Lab Could be Used to Reduce Nerve Pain

February 18 , 2016

The Mount Desert Island Biological Laboratory has made advances in studies involving zebrafish under a $1 million grant from the National Institutes of Health. Read more...


Estrogens Suppress a Behavioral Phenotype in Zebrafish Mutants of the Autism Risk Gene, CNTNAP2

February 18 , 2016

Autism spectrum disorders (ASDs) are a group of devastating neurodevelopmental syndromes that affect up to 1 in 68 children. Despite advances in the identification of ASD risk genes, the mechanisms underlying ASDs remain unknown. Homozygous loss-of-function mutations in Contactin Associated Protein-like 2(CNTNAP2) are strongly linked to ASDs. Read more...


Check this Video: A new Molecular Alarm Clock in Vertebrates

February 17 , 2016

Dozens of chemical interactions in the vertebrate brain go into maintaining a natural sleep schedule, and scientists have recently found one more player on the field: a neurochemical called neuromedin U, or Nmu. The protein, which was analyzed in zebrafish but is also found in humans, acts to stimulate wakefulness, particularly in the morning. The study appears Feb. 17, 2016 in  Neuron. Read more...


Protein Found Crucial in Vertebrae Formation

February 16 , 2016

In an effort to better understand scoliosis and other vertebrae defects, Yale researchers have examined links between the saw-tooth pattern of a protein and correct spinal formation in zebrafish embryos. Members of the Holley Lab at Yale published their findings in the... Read more...


Sustained Effects of Developmental Exposure to Ethanol on Zebrafish Anxiety-Like Behaviour

February 11 , 2016

In zebrafish developmentally exposed to ambient ethanol, the cortisol response to stress has been shown to be significantly attenuated in larvae, juveniles and 6 month old adults. Read more...


Scientists Watch as Healthy Cells Turn Into Melanoma

February 7 , 2016

Harvard researchers have engineered zebrafish that can be used to visually track melanoma as it begins — from its initiation from neural crest progenitor (NCP)–like cells to full-blown melanoma. The study was published online January 29 in Science. Read more...


Anxiolytic Effects of Fluoxetine and Nicotine Exposure on Exploratory Behavior in Zebrafish

February 7 , 2016

A recent study exposed fish to system water (control), 10 mg/L fluoxetine, or 1 mg/L nicotine for three minutes prior to being subjected to four minutes in an open-field drop test. Video recordings were tracked using ProAnalyst. Fish from both drug treatments reduced swimming speed, increased vertical position, and increased use of the top half of the open field when compared with the control, though fluoxetine had a larger effect on depth related behaviors while nicotine mostly affected swimming speed. a significant sex effect was observed where females swam at a slower and more constant speed than males, however neither drug produced a sex-dependent response.  Read more...


Chemical Used to Replace BPA in Plastic Accelerates Embryonic Development, Disrupts Reproductive System

February 3 , 2016

A recent study shows that making plastic products with BPA alternatives does not necessarily leave them safer, said Nancy Wayne, the study’s senior author, a reproductive endocrinologist and professor of physiology at the David Geffen School of Medicine at UCLA. "Our findings are frightening — consider it the aquatic version of the canary in the coal mine."  Read more...


A Cancer's Surprise Origins, Caught in Action

January 29 , 2016

Researchers at Boston Children's Hospital have, for the first time, visualized the origins of cancer from the first affected cell and watched its spread in a live animal.  Read more...


Success of Diabetic Drugs – A Short Review

January 29 , 2016

In August last year, Johns Hopkins scientists reported success using zebrafish embryos to identify potential new diabetes drugs. In the study, more than 500,000 zebrafish embryos were analyzed. Eventually, the researchers identified 24 compounds that effectively increased beta cell number in these animals. Besides identify... Read more...


Estrogens Alleviate Hyperactivity in Zebrafish with Autism Gene

January 29 , 2016

The scientists set out to investigate the function of genes linked to autism and  seizures  in humans by using zebrafish as a model system. They unexpectedly found that estrogens have a selective effect in calming hyperactive  fish during the night which will help scientists to understand the brain pathways affected in ASD. Read more...


Short Telomeres in Key Tissues Initiate Local and Systemic Aging in Zebrafish

January 28 , 2016

Telomeres shorten with each cell division and telomere dysfunction is a recognized hallmark of aging. Tissue proliferation is expected to dictate the rate at which telomeres shorten. We set out to test whether proliferative tissues age faster than non-proliferative due to telomere shortening during zebrafish aging. We performed a prospective study linking telomere length to tissue pathology and disease. Read more...


Modeling GATAD1-Associated Dilated Cardiomyopathy in Adult Zebrafish

January 27 , 2016

Specifically, we studied the zebrafish homologue of  GATAD1 , a recently identified gene for adult-onset autosomal recessive DCM. We showed cardiac expression of  gatad1  transcripts, by whole mount  in situ  hybridization in zebrafish embryos, and demonstrated nuclear and sarcomeric I-band subcellular localization of Gatad1 protein in cardiomyocytes, by injecting a Tol2 plasmid encoding fluorescently-tagged Gatad1. Read more...


A New Anaesthetic Protocol for Adult Zebrafish (Danio rerio): Propofol Combined with Lidocaine

January 25 , 2016

The increasing use of zebrafish model has not been accompanied by the evolution of proper anaesthesia for this species in research. The most used anaesthetic in fishes, MS222, may induce aversion, reduction of heart rate, and consequently high mortality, especially during long exposures. Therefore, we aim to... Read more...


Genome-wide Transcriptional Analysis of Silica Nanoparticles-induced Toxicity in Zebrafish Embryos

January 20 , 2016

Gene ontology analysis showed that SiNPs caused significant changes in gene expression patterns related to many important functions, including response to stimuli, immune response, cellular process, and embryonic development. Read more...


Why Zebrafish Stripes are Horizontal? Animal Patterns Follow a Mathematical Formula

January 19 , 2016

The research is published in the journal Cell Systems. The paper is titled "Orientation of Turing-like Patterns by Morphogen Gradients and Tissue Anisotropies." Read more...


Motor Neurons and Locomotion: Even More Complex Than We Thought

January 17 , 2016

Groundbreaking research published in Nature this week shows that the role of motor neurons in locomotion is far more complicated than neuroscientists previously believed. Read more...


How to Regenerate a Zebrafish Heart

January 14 , 2016

Researchers at the Hubrecht Institute have applied new tools to better understand how the zebrafish heart regenerates after injury. The article is published in Developmental Cell this week. Read more...


Motor Behavior Mediated by Continuously Generated Dopaminergic Neurons in the Zebrafish Hypothalamus Recovers after Cell Ablation

January 7 , 2016

Postembryonic neurogenesis has been observed in several regions of the vertebrate brain, including the dentate gyrus and rostral migratory stream in mammals, and is required for normal behavior. Read more...


Fish May Also Have Emotions And Consciousness: Study

December 10 , 2015

In a study featured in the journal  Proceedings of the Royal Society of London, Biological Sciences , scientists from the University of Bristol and University of Stirling in the United Kingdom and the Universitat Autònoma de Barcelona (UAB) in Spain observed that when zebrafish (Danio rerio) experience stress, the temperature of their body rises by around two to four degrees. Read more...


Cell News - Zebrafish Help Determine Cause of Differences in Severity of Titin Myopathies

December 9 , 2015

Scientists used CRISPR/Cas9 to generate zebrafish with various Titin mutations and were able to identify the precise location that led to varying disease severity, which they could rescue with a protein fragment. Read more...


Personalized medicine studies in zebrafish reveal gene targets for epilepsy

December 5 , 2015

Technological advances ranging from gene editing to next-generation sequencing offer unprecedented access to the human genome and promise to reshape the diagnosis and treatment of epilepsy. Read more...


Highly sensitive sensors successfully map electrical patterns of embryonic heart

November 9 , 2015

The study could lead to new insight into how heart rhythm abnormalities develop, the researchers say.  The team fine-tuned patented Electric Potential Sensing (EPS) technology, developed at the University, to detect the electrical signals of zebrafish embryos from just three days after fertilization. Read more...


Dr. Henry Krause's Lab Uses Zebrafish to Detect Toxic Drug Effects. See-through fish offer clear advantage to drug researchers

November 9 , 2015

Genetically modified zebra fish whose organs glow fluorescent green will help pharmaceutical researchers test new products, say scientists at the University of Toronto. Read more...


THE PLASTIC USED IN 3D PRINTERS IS TOXIC TO SOME FISH ...AND POSSIBLY TO HUMANS

November 9 , 2015

Toxins from 3D printed plastic discs disrupted the development of zebrafish embryos, according to a study published last week in the journal Environmental Science and Technology Letters. Read more...


Studies in Zebrafish Larvae Found New Details about How Melatonin Triggers Sleep

October 15 , 2015

Researchers investigated the sleep-related functions of melatonin in zebrafish larvae.  The results strongly suggest there is a direct role for melatonin in both falling asleep and in sleeping for a normal, healthy duration throughout the night. Read more...


Zebrafish Lead to New Breakthrough in the Fight Against Muscular Dystrophy

October 13 , 2015

New research published today in the journal eLife has demonstrated a new method for observing the behaviour of the protein Dystrophin in a living animal cell, in real-time. This breakthrough may provide a key to understanding how to treat the genetic disease, Muscular Dystrophy. Read more...


Check this NHI Videocasting "The Zebrafish Guide to Tuberculosis"

October 9 , 2015

Read more...


A Transparent Fish Shows How Meningitis Moves Through The Body And Attacks The Brain

October 1 , 2015

Researchers at Duke University Medical Center, created a video showing how Cryptococcal  meningitis takes over the brain. Using a transparent fish, the resulting images look like something straight out of a sci-fi movie teaser... Read more...


Zebrafish inspired innovative “protein patch” shows possibility of cell regeneration after heart attack.

September 19 , 2015

An innovative therapeutic strategy, inspired by zebrafish, is a patch made of acellular collagen that simulates fetal epicardial tissue and is embedded with FSTL1. The two substances are absorbed by tissue of a damaged heart and... Read more...


Researchers identify protein that regulates neuron growth

September 19 , 2015

An international team of researchers, led by scientists at the National University of Singapore (NUS), has identified a protein that regulates the growth of neurons by transporting key metabolic enzymes to the tips of neural cells.  The research team looked at the biological roles of BNIP-H in cell lines, primary neuron cultures and zebrafish using molecular genetics, protein biochemistry and high speed imaging... Read more...


Identification of new molecular components of the kidney filtration barrier opens up possibilities to study their role in diseases

September 17 , 2015

Studies in zebrafish larvae indicate that Tmem234 is essential for the organization and functional integrity of the pronephros filtration barrier as knockdown of Tmem234 expression results in foot process effacement and proteinuria. In summary, we have identified... Read more...


Norepinephrine is required to promote wakefulness and for hypocretin-induced arousal in zebrafish

September 17 , 2015

Pharmacological studies in mammals suggest that norepinephrine (NE) plays an important role in promoting arousal. However, the role of endogenous NE is unclear, with contradicting reports concerning the sleep phenotypes of mice lacking NE due to mutation of dopamine ß-hydroxylase (dbh). To investigate NE function in an alternative vertebrate model, we generated dbh mutant zebrafish. Read more...


Lessons from Xenopus, Zebrafish, and Mouse Studies

September 14 , 2015

A complete understanding of the mechanisms underlying nephrogenesis in different model organisms will provide novel insights on the etiology of several human renal diseases. Read more...


Mutant Glowing-Brained Zebrafish Might Help Explain How Our Brains Work

September 11 , 2015

The newest research group at the Nobel prize-wining Kavli Institute for Systems Neuroscience in Norway  plans to use genetically modified zebrafish  to study how brains work when the creatures are just swimming about and living their fishy lives. Read more...


Kansas City Researchers Say Zebrafish May Hold Clue To Reversing Deafness In Humans

September 10 , 2015

The researchers are among a growing body of scientists who propose that, through the study of animal cell growth, they can learn how to activate similar regenerative abilities in humans and possibly reverse hearing loss. Read more...


Zebrafish Research Provides Clues on Autism

September 4 , 2015

Researchers are utilizing animal models to understand how dysfunction of either of two genes associated with ASD,  SYNGAP1  and  SHANK 3,  contributes to risk in ASD. The new findings pinpoint the actual place and time where these genes exert influence in brain development and function. The findings are published in the journal  Human Molecular Genetics. Read more...


Zebrafish Contributes to Findings in the Development of Cataracts

August 28 , 2015

Now in a paper  published online by the journal  Experimental Eye Research , Mchaourab and colleagues including Wenbiao Chen, Ph.D., and Ela Knapik, M.D., have shown that the alpha-A crystallin plays an evolutionarily conserved role between the zebrafish and the rat.  When the researchers disrupted the expression of the alpha crystallin genes, the fish developed cataracts.  Read more...


How Zebrafish rebuild the skeleton of amputated fins

August 24 , 2015

Fish, in contrast to humans, have the fascinating ability to fully regenerate amputated organs. The zebrafish ( Danio rerio ) is a popular ornamental fish. When parts of its tailfin are injured by predators, or are experimentally amputated, the lost tissue is replaced within three weeks. Zebrafish therefore... Read more...


Features of a pathogen that infects fish a could possibly work as a cancer treatment in the future

July 29 , 2015

Though the research is in its early stages, researchers believe they may have found a potential new route for treating cancer — through a pathogen that causes redmouth disease in  Salmonidae  fish, which includes salmon and trout. The researchers, from the University of Freiburg in Germany, published their study in  Nature Communications. Read more...


Salmonid fish toxin could be effective against cancer

July 28 , 2015

A fish toxin could be the basis of a new treatment for cancer, according to a study. This has been found by performing genetic testing on the humble zebrafish. Read more...


Zebrafish Reveal Drugs that May Improve Bone Marrow Transplant

July 28 , 2015

Using la rge-scale zebrafish drug-screening models, Harvard Stem Cell Institute (HSCI) researchers at Boston Children's Hospital have identified a potent group of chemicals that helps bone marrow transplants engraft or “take.”

The findings, featured on the cover of the today's issue of  Nature , could lead to human trials in patients with cancer and blood disorders within a year or two, says senior investigator  Leonard Zon , a member of the HSCI executive committee and a professor in Harvard's Department of Stem Cell and Regenerative Biology. Read more...


Flexible and waterproof micro-sensors to uncover zebrafish circadian rhythms: The next generation of cardiac monitoring for drug screening

July 28 , 2015

Flexible electronics are the next generation of sensors for mobile health and implantation. Zebrafish (Danio rerio) is an emergent strategy for pre-clinical drug development and toxicity testing. To address the confounding effects from sedation of fish and removal from the aquatic habitat for micro-electrocardiogram (µECG) measurements, we developed waterproof and wearable sensors to uncover the circadian variation in heart rate (HR) and heart rate variability (HRV) ( Massin et al., 2000). The parylene-C based ECG sensor consisted of an ultra-soft silicone integrated jacket designed to wrap around the fish during swimming. Read more...


Clarkson biology professor Cintia Hongay awarded $350,000 for research project

July 26 , 2015

POTSDAM -- A Clarkson biology professor was awarded nearly $350,000 by the National Institute . Read more...


Does a fish hold the key to generating the heart after a heart attack?

July 8 , 2015

New program at USC labs  aims to stimulate new interdisciplinary stem cell research projects initiated and proposed by students and postdocs. Read more...


Zebrafish on the path to fight cancer and other diseases

July 2 , 2015

A relatively new method of targeting specific DNA sequences in zebrafish could dramatically accelerate the discovery of gene function and the identification of disease genes in humans, according to scientists at the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH). Read more...


Zebrafish provide a novel model to study short bowel syndrome

July 2 , 2015

Investigators at Children's Hospital Los Angeles are providing new hope for babies with short bowel syndrome (SBS) by developing a novel model of SBS in zebrafish, described in a paper published online on June 18 by the  American Journal of Physiology-Gastrointestinal and Liver Physiology. Read more...


Live imaging reveals how wound healing influences cancer

July 2 , 2015

Researchers in the United Kingdom and Denmark have studied the "see-through" larvae of zebrafish to reveal how wound healing leads to skin cancer. Live imaging shows neutrophils, the protective inflammatory cells of the body's immune system . Read more...


Zebrafish provide a novel model to study short bowel syndrome

June 24 , 2015

The findings show that disrupting the expression or “knocking down” either SYNGAP1 or SHANK 3 genes affects early brain development in the mid and hindbrain regions and results in hyper-excitable behaviors. Read more...


A New method could dramatically accelerate the discovery of gene functions and the identification of disease genes in humans.

June 8 , 2015

In a recent study, researchers reported that the gene-editing technology known as CRISPR/Cas9 is six times more effective than other techniques at homing in on target genes and inserting or deleting specific sequences. Read more...


How the upgraded zebrafish facility at Boston Children's will boost drug research

May 27 , 2015

The hospital showcased a $4 million upgrade to the hospital's zebrafish facility, thanks to the Massachusetts Life Sciences Center, which will ensure the region stays at the forefront of such research for years to come. Read more...


New zebrafish model should speed research on parasite that causes toxoplasmosis

May 27 , 2015

Researchers at Oregon State University have found a method to speed the search for new therapies to treat toxoplasmosis – by successfully infecting zebrafish with Toxoplasma gondii. Read more...


Study Uncovers Foundations of Heart Regeneration

May 5 , 2015

A study appearing May 4 in the journal  Nature  found that when this critical layer of the  heart  is damaged, the whole repair process is delayed as the epicardium undergoes a round of self-healing before tending to the rest of the heart. Read more...


Time-Lapse Video of Zebrafish "Inner Ear" Development Wins 1st Place in Nikon Small World in Motion Competition

April 30, 2015

Dr. Mariana Muzzopappa (of the Institute for Research in Biomedicine Barcelona) and Jim Swoger (of the Center for Genomic Regulation, Barcelona) won the Fourth Annual Nikon Small World in Motion Photomicrography Competition, for their stunning capture of the development of a zebrafish lateral line - a process that could provide insight into curing deafness in humans. See videos. Read more...


How tiny fish help unlock the secrets of cancer

April 27, 2015

Read more...


Zebrafish accelerate research against pancreatic cancer

April 7, 2015

Today, scientists at the Translational Genomics Research Institute (TGen) are using  zebrafish  to accelerate investigations of  pancreatic cancer , the nation's fourth-leading cause of cancer-related death. Read more...


Evolutionary Novelties in Vision

April 1 , 2015

David Lagman and co-workers from SciLife Uppsala University, describe evolutionary changes in the first relay step in the vision cascade, mediated by a family of G-proteins called transducins. These trigger the cellular response by activating a critical enzyme. Read more...


Self-repairing hearts studied

March 27, 2015

Research teams in the US and in Europe this week publish separate studies suggesting it may be possible to stimulate human hearts to repair themselves after a heart attack. Read more...


Zebrafish helps investigate about eye disease which causes severe vision loss and blindness in infants

March 23, 2015

Researchers from Glasgow Caledonian University (GCU) are  working to investigate Leber's Congenital Amaurosis (LCA).
LCA is a rare degenerative genetic condition affecting the retina, which can cause severe vision loss and blindness in young children.. Read more...


Zebrafish May Be Key to Beating Osteoporosis

March 10, 2015

The ability of the fish to rebuild itself is partly why scientists at the National University of Singapore (NUS) are studying it. They want to find out how to beat osteoporosis, a disease that causes bones to waste away faster than usual and become prone to fracture.. Read more...


Scientists find link between flame retardants and obesity

March 4, 2015

Scientists at UH's Center for Nuclear Receptors and Cell Signaling (CNRCS) have been researching the issue using zebrafish. The researchers set out to screen for compounds that lead to obesity, called obesogens... Read more...


Epigenome orchestrates embryonic development

February 23, 2015

Studying zebrafish embryos, researchers at  Washington University School of Medicine  in St. Louis have shown that the epigenome plays a significant part in guiding development in the first 24 hours after fertilization. 

The research, which appears Feb. 20 in the journal Nature Communications, may deepen understanding of congenital defects and miscarriage... Read more...


Howard Hughes Medical Institute Develops New Tool to Track Brain Activity in Fish

February 14, 2015

New Fluorescent Protein A new tool developed at the Howard Hughes Medical Institute's Janelia Research Campus lets scientists shine a light on an animal's brain to permanently mark neurons that are active at a particular time. The tool -- a fluorescent protein called CaMPARI -- converts from green to red when calcium floods a nerve cell after the cell fires... Read more...


Zebrafish in Orbit!

February 9, 2015

A trip of zebrafish aboard NASA’s International Space Station could lead to the discovery of new drugs or treatments for patients on extended bed rest or with limited mobility... Read more...


BPA and BPS can cause Hyperactivity among Zebrafish

January 14, 2015

In a study published in the Proceedings of the National Academy of Sciences (PNAS) , researchers in Deborah Kurrasch's lab at the University of Calgary have provided evidence that BPA and BPS cause alterations in brain development leading to hyperactivity in zebrafish... Read more...


Research group identifies GLUT2 protein's role in zebrafish brain development

January 14, 2015

Researchers from the University of Barcelona (UB) have described the key role that GLUT2 protein plays in embryonic brain development in zebrafish. A new article —highlighted on the cover of the January issue of the Journal of Cerebral Blood Flow & Metabolism — proves that this molecule... Read more...


 
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